Case study in neonatology

Abstract

Neonatology represents per se a challenging clinical setting, where decisionmaking faces multifaceted issues and where the conduct of high-quality and large randomised trials is not easy. Umbrella reviews, overviews of reviews and meta-epidemiologic studies offer an important and effi cient set of tools to integrate the evidence base in this peculiar discipline, while pinpointing areas of uncertainty either because of poor precision in effect estimates or at risk of inaccuracy due to sources of bias.