The development of tumor-specific T cell tolerance is largely responsible for tumor escape. Accumulation of myeloid-derived suppressor cells (MDSCs) in animal tumor models as well as in cancer patients is involved in tumor-associated T cell tolerance. In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter. © 2007 Springer Science+Business Media, LLC.
CITATION STYLE
Nagaraj, S., & Gabrilovich, D. I. (2007). Myeloid-derived suppressor cells. In Advances in Experimental Medicine and Biology (Vol. 601, pp. 213–223). https://doi.org/10.1007/978-0-387-72005-0_22
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