Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-β). Chlamydial infection inhibited IFN-γ-induced expression of HLA-DR antigen in the cells. Addition of IFN-β antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-β.
CITATION STYLE
Rodel, J., Groh, A., Vogelsang, H., Lehmann, M., Hartmann, M., & Straube, E. (1998). Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma interferon-induced HLA-DR expression. Infection and Immunity, 66(9), 4491–4495. https://doi.org/10.1128/iai.66.9.4491-4495.1998
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