Background: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results: A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10-8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10-5 from the GWAS. Conclusions: We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.
CITATION STYLE
Westphal, S., Stoppe, C., Gruenewald, M., Bein, B., Renner, J., Cremer, J., … Roewer, N. (2019). Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study. BMC Cardiovascular Disorders, 19(1). https://doi.org/10.1186/s12872-019-1002-x
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