In this chapter, we mainly discuss the expression and function of aquaporins (AQPs) expressed in digestive system. AQPs in gastrointestinal tract include four members of aquaporin subfamily: AQP1, AQP4, AQP5 and AQP8, and a member of aquaglyceroporin subfamily: AQP3. In the digestive glands, especially the liver, we discuss three members of aquaporin subfamily: AQP1, AQP5 and AQP8, a member of aquaglyceroporin subfamily: AQP9. AQP3 is involved in the diarrhea and inflammatory bowel disease; AQP5 is relevant to gastric carcinoma cell proliferation and migration; AQP9 plays considerable role in glycerol metabolism, urea transport and hepatocellular carcinoma. Further investigation is necessary for specific locations and functions of AQPs in digestive system.
CITATION STYLE
Zhu, S., Ran, J., Yang, B., & Mei, Z. (2017). Aquaporins in digestive system. In Advances in Experimental Medicine and Biology (Vol. 969, pp. 123–130). Springer New York LLC. https://doi.org/10.1007/978-94-024-1057-0_8
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