Full details of an enantioselective total synthesis of 8-O-4'-neolignan perseal B are presented for the first time. The synthesis was achieved in 8 steps from vanillin and involved the asymmetric dihydroxylation reaction using AD-mix-α to give the key intermedium (1S,2S)-1-(4-(benzyloxy)-3- methoxyphenyl)propane-1,2,3-triol, and the Mitsunobu reaction between phenylpropanoid and vanillin formed perseal B. The synthetic method of perseal B exhibits a new route for 8-O-4'-neolignan. © TUBITAK.
CITATION STYLE
Xia, Y. M., Wang, W., Guo, Y. L., & Li, J. F. (2010). Asymmetric synthesis of 8-O-4′-neolignan perseal B. Turkish Journal of Chemistry, 34(3), 375–380. https://doi.org/10.3906/kim-0908-201
Mendeley helps you to discover research relevant for your work.