Role of STAT3 in Pancreatic Cancer: A target for therapy

1Citations
Citations of this article
1Readers
Mendeley users who have this article in their library.
Get full text

Abstract

STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

Author supplied keywords

Cite

CITATION STYLE

APA

Daddacha, W. B., Koyen, A. E., Schlafstein, A. J., & Yu, D. S. (2018). Role of STAT3 in Pancreatic Cancer: A target for therapy. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 339–348). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_24

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free