STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.
CITATION STYLE
Daddacha, W. B., Koyen, A. E., Schlafstein, A. J., & Yu, D. S. (2018). Role of STAT3 in Pancreatic Cancer: A target for therapy. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 339–348). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_24
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