Evaluation of susceptibility patterns and BRO β-lactamase types among clinical isolates of Moraxella catarrhalis

Abstract

The aims of this study were to detect BRO β-lactamase types and to evaluate any correlation with the susceptibility patterns of 90 clinical isolates of Moraxella catarrhalis . The overall prevalences of the bro -1 and bro -2 genes were 78% and 12%, respectively. Penicillin G MICs for BRO-1+ isolates were significantly higher than those for BRO-2+ isolates. All the isolates were susceptible to amoxycillin-clavulanate, levofloxacin and cefixime. Resistance to clarithromycin, tetracycline and trimethoprim-sulphamethoxazole was 1.1%, 2.2% and 1.1%, respectively. One-step, length-based PCR was an efficient method to screen for BRO β-lactamase genes. © 2007 The Authors Journal Compilation 2007 European Society of Clinical Microbiology and Infectious Diseases.