Mutations in the α-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster

29Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Drosophila melanogaster oocytes heterozygous for mutations in the α- tubulin 67C gene (αtub67C) display defects in centromere positioning during prometaphase of meiosis I. The centromeres do not migrate to the poleward edges of the chromatin mass, and the chromatin fails to stretch during spindle lengthening. These results suggest that the poleward forces acting at the kinetochore are compromised in the αtub67C mutants. Genetic studies demonstrate that these mutations also strongly and specifically decrease the fidelity of achiasmate chromosome segregation. Proper centromere orientation, chromatin elongation, and faithful segregation can all be restored by a decrease in the amount of the Nod chromokinesin. These results suggest that the accurate segregation of achiasmate chromosomes requires the proper balancing of forces acting on the chromosomes during prometaphase.

Cite

CITATION STYLE

APA

Matthies, H. J. G., Messina, L. G., Namba, R., Greer, K. J., Walker, M. Y., & Hawley, R. S. (1999). Mutations in the α-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster. Journal of Cell Biology, 147(6), 1137–1144. https://doi.org/10.1083/jcb.147.6.1137

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free