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B16 lung melanoma model to study the role of Th9 cells in cancer

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Abstract

T cell therapy has shown remarkable promise in multiple malignancies including melanoma and Acute Lymphoblastic Leukemia (ALL). Recent data demonstrated the differential efficacy of various subsets of T-helper cells in tumor regression. Th9 cells, the new member of T helper cell family, possess superior anti-tumor activity compared to Th1 and Th2 cells in murine model of melanoma. Therefore, it is important to examine the anti-tumor activity of specific subsets of Th cells in tumor models. Here, we describe the methodology of examining the anti-tumor activity of Th9 cells in murine model of melanoma.

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Dwivedi, A., Kumar, S., & Purwar, R. (2017). B16 lung melanoma model to study the role of Th9 cells in cancer. In Methods in Molecular Biology (Vol. 1585, pp. 217–222). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6877-0_17

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