Oral Controlled Delivery Mechanisms and Technologies

Abstract

This chapter reviews release mechanisms and corresponding technologies used to control drug release from oral dosage forms. Products utilizing such approaches range from simple matrix systems to those employing more complex osmotic delivery technologies. Technologies including Oros™, gastroretentive devices, TIMERx™, Contramid™, Geomatrix™, and SODAS™ are discussed. These approaches are generally utilized to provide once-daily administration but some can also be used for differential release of more than one drug from the same dosage form or timed release of drug to align with time of clinical need. © Controlled Release Society 2011.