Nine biotinylated Grubbs-Hoveyda and Grubbs-type metathesis catalysts were synthesized and evaluated in ring closing metathesis reactions of N-tosyl diallylamine and 5-hydroxy-2-vinylphenyl acrylate. Their catalytic activity in organic-and aqueous solvents was compared with the second generation Grubbs-Hoveyda catalyst. The position of the biotin-moiety on the N-heterocyclic carbene was found to critically influence the catalytic activity of the corresponding ruthenium-based catalysts. © Springer Science+Business Media New York 2013.
CITATION STYLE
Kajetanowicz, A., Chatterjee, A., Reuter, R., & Ward, T. R. (2014). Biotinylated metathesis catalysts: Synthesis and performance in ring closing metathesis. Catalysis Letters, 144(3), 373–379. https://doi.org/10.1007/s10562-013-1179-z
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