The flatworm nervous system: pattern and phylogeny.

Abstract

The flatworms occupy a position at the base of the metazoan phylogenetic tree; they have a bilateral symmetric nervous system and an archaic brain. The following aspects, brought into focus by the use of new methods, will be dealt with in the present paper. 1. The high degree of diversity on all levels of the flatworm nervous system (NS). 2. The concept of main nerve cords is defined and the use of this concept in avoiding confusions in the terminology of nerve cords is stressed. 3. The archaic nature of the stomatogastric NS is reviewed. 4. The new data about neuronal celltypes implying advanced features at this low phylogenetic level. 5. The ultrastructural studies of neuronal cells indicating (A) that a common secretory cell type containing dense-core vesicles is archaic and a likely progenitor cell type for conventional neurons of advanced flatworms and (B) that an independent evolution of synaptic structures and glial cells has occurred inside the flatworm taxon. 6. The multitude of neuroactive substances demonstrated by light microscopic histofluorescence, immunocytochemistry, liquid chromatography, and HPLC. The cholinergic, aminergic, and peptidergic substances often occur in different neuronal compartments.