Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these extensive projections and interactions orexins are involved in numerous functions, such as feeding behavior, neuroendocrine regulation, the sleep-wake cycle and reward-seeking. This review will summarise the literature to date which has evaluated a role of orexins in the behavioral effects of alcohol, with a focus on understanding the importance of this peptide and its potential as a clinical therapeutic target for alcohol use disorders. © 2012 Kim, Brown and Lawrence.
CITATION STYLE
Kim, A. K., Brown, R. M., & Lawrence, A. J. (2012, October 26). The role of orexins/hypocretins in alcohol use and abuse: An appetitive-reward relationship. Frontiers in Behavioral Neuroscience. https://doi.org/10.3389/fnbeh.2012.00078
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