Isolation of stigmasterol from hexane extract of leaves of Pisonia grandis R.Br, in vitro anti-diabetic and its molecular docking studies

0Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Pisonia grandis R.Br belonging to the family Nyctaginaceae is a widely dis-tributed evergreen tree in India known for its medicinal uses. The study was aimed to investigate the anti-diabetic property in the leaves of Pisonia gran-dis R.Br. The isolation and purification were performed by the conventional column chromatography and the resultant yield was found to be a white crys-talline powder, which was further subjected for characterisation through IR,1H NMR,13C NMR and mass spectroscopy. From the characterisation data, the isolated compound was identified as stigmasterol; it was first time isolated from the hexane extract of the leaves. The α-amylase inhibitory activity of stigmasterol from the hexane extract of the leaves of Pisonia grandis R.Br showed high potent activity with an IC50 value of 46 µg/mL. The anti-diabetic activity of the compound against α-amylase and four other diabetic enzymes-α-glucosidase, acid phosphatase, endo-β-N-acetylglucosaminidase and β-glucuronidase were further investigated by molecular docking studies and proved that stigmasterol can be a potential anti-diabetic agent.

Cite

CITATION STYLE

APA

Mitra, A., Ramasamy, M., Parthiban, V., Teja, T. R., Vemuri, S., & Kaliappan, I. (2020). Isolation of stigmasterol from hexane extract of leaves of Pisonia grandis R.Br, in vitro anti-diabetic and its molecular docking studies. International Journal of Research in Pharmaceutical Sciences, 11(2), 2117–2122. https://doi.org/10.26452/ijrps.v11i2.2158

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free