Perbandingan Efek Induksi Propofol dengan Ketamin terhadap Penurunan Nilai Neutrofil pada Pasien dengan Tindakan Anestesi Umum

Abstract

Leukocyte is a part of innate immunity elements. Neutrophil impairment of can be used as a simple parameter to measure the severity of stress and systemic inflammation in patients. Some research suggests the influence of anesthetic drugs on leukocytes and other studies look at the effect of anesthetic drugs on leukocyte subset functions, especially neutrophils. This study aimed to reveal the difference in the induction effect of propofol and ketamine against impairment of neutrophils in patients with general anesthesia. This was a double blind randomized control trial conducted in 32 patients ASA I and II who were divided into two groups. These patients underwent general anesthesia at the Central Operating Theater of H. Adam Malik General Hospital during May–June 2016. Group propofol (A) received 2 mg/kgBW propofol, while group ketamine (B) received 2 mg/kgBW ketamine. Neutrophils were measured before induction (T1), 10 minutes after intubation (T2), and 60 minutes after intubation (T3). By using T-independent and Mann- Whitney U test in SPSS ver.23, it was found that the the p-values for T1. T2, and T3 neutrophils were0.636, 0.846, and 0.403. respectively. In conclusion, there is a difference in induction effect between propofol and ketamine against impairment of neutrophils with no effect is found for propofol.