Methods of myofibrillogenesis modeling

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Abstract

Organization in the heart is important on multiple length scales. Myofibrillogenesis processes control the assembly of this multi-scale architecture. Understanding myofibrillogenesis might allow us to better control self-assembly of cardiac tissues. One approach consists of creating phenomenological models and comparing these models to in vitro data from primary myocytes. In this chapter, we present a method for building these models to recapitulate different aspects of myofibrillogenesis. We present a specific example for a cardiomyocyte model, but the same procedure can be used to model fibrillogenesis with other mechanisms such as motility. In sum, the models allow for a better understanding of mechanisms behind self-assembly.

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Drew, N. K., & Grosberg, A. (2015). Methods of myofibrillogenesis modeling. In Cardiomyocytes: Methods and Protocols (pp. 75–91). Springer New York. https://doi.org/10.1007/978-1-4939-2572-8_6

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