Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.

  • Saito T
  • Weiss A
  • Gunter K
  • et al.
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Abstract

We have identified a surface T3- Jurkat variant which has a defective alpha-chain but which possesses an intact beta-chain. The transfection of a functional mouse alpha-chain into this human T cell induces the expression of surface T3 molecules associated with mouse alpha-human beta-heterodimers detected by anticlonotypic antibodies. Treatment of the transfectant with anti-T3, anti-mouse Ti-alpha, or anti-human Ti-beta antibodies clears all Ti-T3 complexes from the surface. These results demonstrate that functional alpha- and beta-chains are both required for expression of T3 on the cell membrane, and that the Ti heterodimers present and associated with T3 on Jurkat cells involve only alpha- and beta-chains.

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Saito, T., Weiss, A., Gunter, K. C., Shevach, E. M., & Germain, R. N. (1987). Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. The Journal of Immunology, 139(2), 625–628. https://doi.org/10.4049/jimmunol.139.2.625

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