Selective binding to polymers via covalent bonds. the construction of chiral cavities as specific receptor sites

Abstract

Separations of substances on polymers by fast and reversible covalent interactions are discussed. For this type of chemoselective affinity chromatography suitable new binding groups were developed for diols, monoalcohols and amines. The selectivity of the separations can be improved by cooperative binding of substrates via two or more binding groups. Polymers with binding groups located in a definite spatial proximity and cooperativity in cavities of specific shape show high selectivity e.g. for the resolution of racemates. These cavities can be looked at as models for natural receptor sites. © 1982 Walter de Gruyter. All rights reserved.