Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth

5Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4-positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4-positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4-positive neurons.

Cite

CITATION STYLE

APA

Zhou, L. Y., Han, F., Qi, S. B., Ma, J. J., Ma, Y. X., Xie, J. L., … Saijilafu. (2020). Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth. Journal of Cellular and Molecular Medicine, 24(18), 11012–11017. https://doi.org/10.1111/jcmm.15648

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free