Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4-positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4-positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4-positive neurons.
CITATION STYLE
Zhou, L. Y., Han, F., Qi, S. B., Ma, J. J., Ma, Y. X., Xie, J. L., … Saijilafu. (2020). Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth. Journal of Cellular and Molecular Medicine, 24(18), 11012–11017. https://doi.org/10.1111/jcmm.15648
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