Passive transmission of autoimmune diseases by allogeneic stem cell transplantation is rare and is ascribed to passive transfer of memory B-cells from donor to recipient. We hereby report a case of transmission of an asymptomatic lupus anticoagulant from a sibling donor to a recipient of transplantation for secondary acute myeloid leukemia. On pre-harvest evaluation, the sibling donor with no history of bleeding or thrombosis was found to have a lupus anticoagulant. After engraftment, the recipient was found to have a new prolonged activated partial thromboplastin time and was subsequently shown to have a lupus anticoagulant on Day +73 after stem cell transplantation. The recipient remained well with no evidence of bleeding, thrombosis, or graft-. versus-host disease and was on a stable dose of tacrolimus at the time the lupus anticoagulant was detected. There was no other identifiable trigger for the appearance of a lupus anticoagulant.
CITATION STYLE
Massoud, M. R., William, B. M., Harrill, K., Cooper, B. W., de Lima, M., & Schmaier, A. H. (2014). Transmission of lupus anticoagulant by allogeneic stem cell transplantation. Revista Brasileira de Hematologia e Hemoterapia, 36(4), 287–289. https://doi.org/10.1016/j.bjhh.2014.05.008
Mendeley helps you to discover research relevant for your work.