In vitro inhibitory potential of methanolic extract of Celosia argentea var. Cristata on tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes

Abstract

In the current study, methanol extract of Celosia argentea var. cristata was tested for its inhibitory potential against tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes at the concentration of 0.5 mM by ELISA microtiter plate assays. A significant tyrosinase inhibitory activity (63.6%), acetylcholinesterase inhibitory activity (80.3%) and butyrylcholinesterse inhibitory activity (68.24%) was shown by crude methanolic extract of C. argentea var. cristata with respective IC 50 values of 268.5 ± 0.2 μg/mL, 73.6 ± 0.1 μg/mL and 132.8 ± 0.9 μg/mL. The result of this study reveals the use of C. argentea var. cristata in skin hyperpigmentation, Parkinson’s disease and neurodegenerative disorders like Alzheimer’s disease and dementia.