We have found a novel type of pluripotent stem cells, Multilineage- differentiating stress enduring (Muse) cells that can be isolated from mesenchymal cell populations. Muse cells are characterized by stress tolerance, expression of pluripotency markers, self-renewal, and the ability to differentiate into endodermal-, mesodermal-, and ectodermal-lineage cells from a single cell, demonstrating that they are pluripotent stem cells. They can be isolated as cells positive for stage-specific embryonic antigen-3, a human pluripotent stem cell marker. Here, we introduce the isolation method for Muse cells and the effect of transplantation of these cells on chronic liver diseases. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Wakao, S., Kitada, M., Kuroda, Y., & Dezawa, M. (2012). Isolation of adult human pluripotent stem cells from mesenchymal cell populations and their application to liver damages. Methods in Molecular Biology, 826, 89–102. https://doi.org/10.1007/978-1-61779-468-1_8
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