High resolution three-dimensional cardiac perfusion imaging using compartment-based k-t principal component analysis

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Abstract

Three-dimensional myocardial perfusion imaging requires significant acceleration of data acquisition to achieve whole-heart coverage with adequate spatial and temporal resolution. The present article introduces a compartment-based k-t principal component analysis reconstruction approach, which permits three-dimensional perfusion imaging at 10-fold nominal acceleration. Using numerical simulations, it is shown that the compartment-based method results in accurate representations of dynamic signal intensity changes with significant improvements of temporal fidelity in comparison to conventional k-t principal component analysis reconstructions. Comparison of the two methods based on rest and stress three-dimensional perfusion data acquired with 2.3 × 2.3 × 10 mm3 during a 225 msec acquisition window in patients confirms the findings and demonstrates the potential of compartment-based k-t principal component analysis for highly accelerated three-dimensional perfusion imaging. © 2010 Wiley-Liss, Inc.

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Vitanis, V., Manka, R., Giese, D., Pedersen, H., Plein, S., Boesiger, P., & Kozerke, S. (2011). High resolution three-dimensional cardiac perfusion imaging using compartment-based k-t principal component analysis. Magnetic Resonance in Medicine, 65(2), 575–587. https://doi.org/10.1002/mrm.22620

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