Remodeling of the interstitial extracellular matrix in white matter multiple sclerosis lesions: Implications for remyelination (failure)

31Citations
Citations of this article
70Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The extracellular matrix (ECM) provides protection, rigidity, and structure toward cells. It consists, among others, of a wide variety of glycoproteins and proteoglycans, which act together to produce a complex and dynamic environment, most relevant in transmembrane events. In the brain, the ECM occupies a notable proportion of its volume and maintains the homeostasis of central nervous system (CNS). In addition, remodeling of the ECM, that is transient changes in ECM proteins regulated by matrix metalloproteinases (MMPs), is an important process that modulates cell behavior upon injury, thereby facilitating recovery. Failure of ECM remodeling plays an important role in the pathogenesis of multiple sclerosis (MS), a neurodegenerative demyelinating disease of the CNS with an inflammatory response against protective myelin sheaths that surround axons. Remyelination of denuded axons improves the neuropathological conditions of MS, but this regeneration process fails over time, leading to chronic disease progression. In this review, we uncover abnormal ECM remodeling in MS lesions by discussing ECM remodeling in experimental demyelination models, that is when remyelination is successful, and compare alterations in ECM components to the ECM composition and MMP expression in the parenchyma of demyelinated MS lesions, that is when remyelination fails. Inter- and intralesional differences in ECM remodeling in the distinct white matter MS lesions are discussed in terms of consequences for oligodendrocyte behavior and remyelination (failure). Hence, the review will aid to understand how abnormal ECM remodeling contributes to remyelination failure in MS lesions and assists in developing therapeutic strategies to promote remyelination.

References Powered by Scopus

Multiple sclerosis

4071Citations
N/AReaders
Get full text

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

1369Citations
N/AReaders
Get full text

Remyelination in the CNS: From biology to therapy

1240Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis

93Citations
N/AReaders
Get full text

Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging

43Citations
N/AReaders
Get full text

Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination

33Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

de Jong, J. M., Wang, P., Oomkens, M., & Baron, W. (2020, July 1). Remodeling of the interstitial extracellular matrix in white matter multiple sclerosis lesions: Implications for remyelination (failure). Journal of Neuroscience Research. John Wiley and Sons Inc. https://doi.org/10.1002/jnr.24582

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 26

67%

Researcher 7

18%

Professor / Associate Prof. 6

15%

Readers' Discipline

Tooltip

Neuroscience 15

38%

Medicine and Dentistry 9

23%

Biochemistry, Genetics and Molecular Bi... 8

21%

Agricultural and Biological Sciences 7

18%

Save time finding and organizing research with Mendeley

Sign up for free