A 32-year-old female, was diagnosed in 2004 with a C1 HIV1 infection, using zidovudine/lamivudine 300/150 mg BID and lopinavir/ritonavir 400/100 mg BID, in addition to prophylaxis with trimethoprim-sulfamethoxazole 800/160 mg QD, but no prophylaxis with macrolide antibiotics. The patient presented with a severe headache and was prescribed two capsules of the anti-migraine drug Ormigrein™, which contained ergotamine tartrate 1 mg, caffeine 100 mg, paracetamol 220 mg, hyoscyamine sulfate 87.5 mcg, and atropine sulfate 12.5 mcg. Afterwards she was prescribed one capsule of Ormigrein every 30 minutes for a total of six capsules a day. The patient took the medication as prescribed but developed a pain in her left ankle three days later, which evolved to the need for amputation.
CITATION STYLE
Ferry, F. R. de A., Da Silva, G. A. R., Motta, R. N., Carvalho, R. de S., & De Sá, C. A. M. (2014). Uso de lopinavir/ritonavir associado com ergotamina resultando em amputação de pé: Comunicação breve. Revista Do Instituto de Medicina Tropical de Sao Paulo, 56(3), 265–266. https://doi.org/10.1590/S0036-46652014000300013
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