A lifetime of allograft function with kidneys from older donors

Abstract

Strategies to increase expanded criteria donor (ECD) transplantation are needed.Wequantified the extent to which ECD kidneys provide recipients with a lifetime of allograft function by determining the difference between patient survival and death-censored allograft survival (graft survival). Initial analyses compared 5-year outcomes in the Eurotransplant Senior Program (European) and the United States Renal Data System. Among European recipients ≥ 65 years, patient survival exceeded graft survival, and ECDrecipients returned to dialysis for an average of 5.2 months after transplant failure. Among United States recipients ≥ 60 years, graft survival exceeded patient survival.Althoughpatient survival in elderly recipients in the United Stateswas low (49% at 5 years), the average difference in patient survival at 10 years in elderly recipients in the United States with an ECD versus non-ECD transplant was only 7 months. The probability of patient survival with a functioning allograft at 5 years was higher with ECD transplantation within 1 year after activation to the waiting list than with delayed non-ECD transplantation ≥ 3 years after activation to the waiting list. Subsequent analyses demonstrated that ECDtransplants do not provide a lifetime of allograft function in recipients ≤50 years in the United States. These findings should encourage ECD transplantation in patients ≥60 years, demonstrate that rapid ECD transplantation is superior to delayed non-ECD transplantation, and challenge the policy in the United States of allowing patients ,50 years to receive an ECD transplant.