Performance comparison of flow-through optofluidic biosensor designs

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Abstract

Optofluidic flow-through biosensors are being developed for single particle detection, particularly as a tool for pathogen diagnosis. The sensitivity of the biosensor chip depends on design parameters, illumination format (side vs. top), and flow configuration (parabolic, two-and three-dimensional hydrodynamic focused (2DHF and 3DHF)). We study the signal differences between various combinations of these design aspects. Our model is validated against a sample of physical devices. We find that side-illumination with 3DHF produces the strongest and consistent signal, but parabolic flow devices process a sample volume more quickly. Practical matters of optical alignment are also discussed, which may affect design choice.

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Wright, J. G., Amin, M. N., Schmidt, H., & Hawkins, A. R. (2021). Performance comparison of flow-through optofluidic biosensor designs. Biosensors, 11(7). https://doi.org/10.3390/bios11070226

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