Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis

18Citations
Citations of this article
47Readers
Mendeley users who have this article in their library.

This artice is free to access.

Abstract

Introduction: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. Objective: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. Methods: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. Results: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p = 0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. Conclusion: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores.

Cite

CITATION STYLE

APA

Kosugi, E. M., Moussalem, G. F., Simões, J. C., de Souza, R. de P. e. S. F., Chen, V. G., Saraceni Neto, P., & Mendes Neto, J. A. (2016). Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis. Brazilian Journal of Otorhinolaryngology, 82(2), 191–197. https://doi.org/10.1016/j.bjorl.2015.03.014

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free