Purpose: The association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk. Methods: PubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs). Results: A total of 18 case–control studies were included in the meta-analysis. We found that there was no statistical significance for ovarian cancer risk following hysterectomy (OR 0.97, 95% CI 0.83–1.12). And in subgroup analysis, the protective effects were observed for invasive endometrioid/clear cell carcinomas after hysterectomy (OR 0.70, 95% CI 0.51, 0.94; I 2 = 0%), and no statistical significance for serous and mucinous. Conclusions: Hysterectomy showed no relationship with ovarian cancer. But a reduced risk was found for endometrioid-invasive OC. These findings could provide evidence for patients with benign gynecological disease and clinicians to make appropriate decision about whether to conduct hysterectomy.
CITATION STYLE
Huo, X., Yao, L., Han, X., Li, W., Liu, J., Zhou, L., … Liu, H. (2019, March 4). Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics. Springer Verlag. https://doi.org/10.1007/s00404-018-5020-1
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