Landscape of coordinated immune responses to H1N1 challenge in humans

12Citations
Citations of this article
30Readers
Mendeley users who have this article in their library.

Abstract

Influenza is a significant cause of morbidity and mortality worldwide. Here we show changes in the abundance and activation states of more than 50 immune cell subsets in 35 individuals over 11 time points during human A/California/2009 (H1N1) virus challenge monitored using mass cytometry along with other clinical assessments. Peak change in monocyte, B cell, and T cell subset frequencies coincided with peak virus shedding, followed by marked activation of T and NK cells. Results led to the identification of CD38 as a critical regulator of plasmacytoid dendritic cell function in response to influenza virus. Machine learning using study-derived clinical parameters and single-cell data effectively classified and predicted susceptibility to infection. The coordinated immune cell dynamics defined in this study provide a framework for identifying novel correlates of protection in the evaluation of future influenza therapeutics.

Cite

CITATION STYLE

APA

Rahil, Z., Leylek, R., Schürch, C. M., Chen, H., Bjornson-Hooper, Z., Christensen, S. R., … McIlwain, D. R. (2020). Landscape of coordinated immune responses to H1N1 challenge in humans. Journal of Clinical Investigation, 130(11), 5800–5816. https://doi.org/10.1172/JCI137265

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free