Neural Synchronization in Parkinson’s Disease on Different Time Scales

Abstract

Parkinson's disease is marked by an elevated neural synchrony in the cortico-basal ganglia circuits in the beta frequency band. This elevated synchrony has been associated with Parkinsonian hypokinetic symptoms. The application of recently developed synchronization analysis techniques allows us to investigate the temporal dynamics of synchrony on different time scales. The results of this analysis are summarized here, revealing highly variable dynamics of synchronized neural activity on multiple time scales and its association with disease. Keywords Parkinson's disease · Neural oscillations · Neural synchronization · Desynchronization · Intermittency · Beta-band oscillations 6.1 Beta-Band Oscillations and Synchronization in Parkinson's Disease Synchronized rhythms of neural activity are widely observed phenomena in the brain and have been studied quite extensively because of their correlations with multiple functions and dysfunctions of neural systems. Neural synchronization plays a crucial role in perception, cognition, and memory, among other processes S. Ahn ()