Redox biology of aging: Focus on novel biomarkers

Abstract

Oxidative stress-mediated damage to functional macromolecules followed by their accumulation has been reported as a major factor behind aging and related consequences. Excessive generation of reactive oxygen species and/or depleted cellular defense impairs the balance between prooxidants and antioxidants causing shift in cellular redox state which leads to physiological dysfunctions making the body prone to external deleterious agents. In the present chapter, we have discussed the aging process and have focused on novel markers of oxidative damage that reflect the cellular redox status relevant to age-related studies incorporating the previously well-established markers of the aging process.