Thyrotoxicosis factitia masquerading as recurrent Graves' disease: Endogenous antibody immunoassay interference, a pitfall for the unwary

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Abstract

Antibody interference in immunoassays is an underestimated problem, which has the potential to cause patient harm and waste health-care resources. We report a case where thyroglobulin antibodies generated a false-positive thyroglobulin result delaying the diagnosis of thyrotoxicosis factitia masquerading as recurrent Graves' disease. A high index of clinical suspicion and good laboratory-clinician communication underpins effective clinical and laboratory strategies to detect potentially erroneous laboratory results due to endogenous antibody interference in immunoassays.

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CITATION STYLE

APA

Jahagirdar, V. R., Strouhal, P., Holder, G., Gama, R., & Singh, B. M. (2008). Thyrotoxicosis factitia masquerading as recurrent Graves’ disease: Endogenous antibody immunoassay interference, a pitfall for the unwary. Annals of Clinical Biochemistry, 45(3), 325–327. https://doi.org/10.1258/acb.2007.007163

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