Absorption: In vitro tests - non cell based

Abstract

The ability to permeate a biological membrane is a prerequisite for oral administered drugs. The primary absorption pathway for the majority of drugs after oral dosage still seems to be the passive transcellular diffusion pathway. A number of methods used in pharmaceutical research to early on estimate the passive absorption potential of a compound by means of a variety of cell free techniques like reversed phase HPLC, artificial membranes or liposomes and PAMPA are described.