The Plasticity of Newly Formed B Cells

  • Giltiay N
  • Giordano D
  • Clark E
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Abstract

Newly formed B cells (NF–B cells) that emerge from the bone marrow to the periphery have often been referred to as immature or transitional B cells. However, NF–B cells have several striking characteristics, including a distinct BCR repertoire, high expression of AID, high sensitivity to PAMPs, and the ability to produce cytokines. A number of findings do not support their designation as immature because NF–B cells have the potential to become Ab-producing cells and to undergo class-switch recombination. In this review, we provide a fresh perspective on NF–B cell functions and describe some of the signals driving their activation. We summarize growing evidence supporting a role for NF–B cells in protection against infections and as a potential source of autoantibody-producing cells in autoimmune diseases such as systemic lupus erythematosus.

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Giltiay, N. V., Giordano, D., & Clark, E. A. (2019). The Plasticity of Newly Formed B Cells. The Journal of Immunology, 203(12), 3095–3104. https://doi.org/10.4049/jimmunol.1900928

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