Disposition of Nanoparticles as a function of Their Interactions with Biomolecules

Abstract

This review focuses on emerging concepts in the fundamental understanding of how particle surfaces interact with components in biological fluids, with an emphasis on how these interactions may inform research regarding the biodistribution of nanosized materials from the portal of entry to other organ systems. The respiratory tract is given particular focus here because of expected occupational and environmental exposure scenarios. Information regarding the biodistribution of nanoparticles and how they might be altered during the process by their local environment is a critical part of a complete human health risk assessment.