To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
CITATION STYLE
Yamayoshi, S., Kiso, M., Yasuhara, A., Ito, M., Shu, Y., & Kawaoka, Y. (2018). Enhanced replication of highly pathogenic influenza A(H7N9) virus in humans. Emerging Infectious Diseases, 24(4), 746–750. https://doi.org/10.3201/eid2404.171509
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