The statistical properties of the two most widely used methods for setting environmental exposure standards are explored. The traditional NOAEL approach handles uncertainty in disagreement with the precautionary principle: a smaller and less sensitive Study will tend to yield higher exposure limits. As an attractive alternative, the Benchmark dose approach estimates the exposure associated with a predefined risk increase above the background. Although advantageous in several respects, this method is sensitive to sources of uncertainty arising from measurement error and data dependent selection of the dose-response model as well the choice of critical endpoint. An improved Benchmark analysis can be conducted using Structural equation models and Bayesian model averaging.
CITATION STYLE
Budtz-Jørgensen, E., Keiding, N., & Grandjean, P. (2009). Approaches to handling uncertainty when setting environmental exposure standards (pp. 267–280). https://doi.org/10.1007/978-90-481-2636-1_12
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