Less is more-ways to move forward for improved breast cancer risk stratification

4Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

Breast cancer risk models increasingly are including mammographic density (MD) and polygenic risk scores (PRS) to improve identification of higher-risk women who may benefit from genetic screening, earlier and supplemental breast screening, chemoprevention, and other targeted interventions. Here, we present additional considerations for improved clinical use of risk prediction models with MD, PRS, and questionnaire-based risk factors. These considerations include whether changing risk factor patterns, including MD, can improve risk prediction and management, and whether PRS could help inform breast cancer screening without MD measures and prior to the age at initiation of population-based mammography. We further argue that it may be time to reconsider issues around breast cancer risk models that may warrant a more comprehensive head-to-head comparison with other methods for risk factor assessment and risk prediction, including emerging artificial intelligence methods. With the increasing recognition of limitations of any single mathematical model, no matter how simplified, we are at an important juncture for consideration of these different approaches for improved risk stratification in geographically and ethnically diverse populations.

Cite

CITATION STYLE

APA

Tehranifar, P., Wei, Y., & Terry, M. B. (2021, April 1). Less is more-ways to move forward for improved breast cancer risk stratification. Cancer Epidemiology Biomarkers and Prevention. American Association for Cancer Research Inc. https://doi.org/10.1158/1055-9965.EPI-20-1627

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free