Skip to main content

Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol–water and liposome–water partition coefficients

10Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol–water and liposome–water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thio-dimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome–water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species.

Cite

CITATION STYLE

APA

Chávez-Capilla, T., Maher, W., Kelly, T., & Foster, S. (2016). Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol–water and liposome–water partition coefficients. Journal of Environmental Sciences (China), 49, 222–232. https://doi.org/10.1016/j.jes.2016.08.007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free