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Drugs for protein misfolding diseases

  • Wrighton K
Nature Reviews Molecular Cell Biology (2015) 16(6) 328-328
DOI: 10.1038/nrm4004
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Abstract

Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) helps to prevent the accumulation of misfolded proteins in the endoplasmic reticulum by decreasing protein synthesis; this phosphorylation is removed by a complex composed of the phosphatase PP1c and its regulatory subunit PPP1R15A. Although the compound guanabenz (GBZ) inhibits PPP1R15A–PP1c, it is…

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APA

Wrighton, K. H. (2015). Drugs for protein misfolding diseases. Nature Reviews Molecular Cell Biology, 16(6), 328–328. https://doi.org/10.1038/nrm4004

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