Abstract
Cardiac neural crest cells (CNCCs) are a subpopulation of cranial neural crest cells that was first described 30 years ago to be required for cardiac outflow septation. Since then the role of the CNCCs in heart development and congenital heart disease has been explored extensively. This chapter will discuss the contributions of the CNCCs to cardiovascular development, the signaling pathways involved in neural crest development, and some of the human congenital heart diseases attributed to aberrant CNCC development.
Author supplied keywords
- 22q11.2 deletion syndrome
- AP-2
- Aorta
- CHARGE syndrome
- CNCCs
- Cardiac neural crest cells
- Conduction system
- Connexin 43
- DiGeorge syndrome
- E-cadherin
- EMT
- Ectoderm
- Ectomesenchymal cells
- Endoderm
- Endothelin-1
- Epithelial-to-mesenchymal transition
- Heart looping
- LEOPARD syndrome
- Nervous system
- Neural tube
- Noonan syndrome
- Outflow tract
- Parathyroid gland
- Patent ductus arteriosus
- Pax3
- Pharyngeal arch arteries
- Pulmonary trunk
- SRY
- Semaphorin
- Snail
- Thymus
- Thyroid gland
- Velocardiofacial syndrome
- Zic1
Cite
CITATION STYLE
Thattaliyath, B., & Hutson, M. (2015). Neural crest. In Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways (pp. 41–54). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-1883-2_4
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