Effect of ketoprofen co-administration and febrile state on pharmacokinetic of cefepime in goats

Abstract

The pharmacokinetic of cefepime (20 mg kg -1) was studied following intramuscular administration of cefepime alone, co-administered with ketoprofen (3 mg kg -1) and under febrile state (Escherichia coli LPS induced) in goats. The concentration of cefepime in serum was detected by using High Performance Liquid Chromatography. Following single dose intravenous administration of cefepime, elimination half life (2.38±0.11 h), area under curve (133.77±3.49 μg h mL -1), body clearance (2.38±0.05 L h -1 kg -1) and volume of distribution (0.5±0.03 L kg -1) were determined. Following single dose intramuscular administration of cefepime alone, peak serum concentration (30.26±2.96 μg mL -1)was obtained at 0.75 h. The absorption half life (t 1/2Kα), volume of distribution (Vd area) total body clearance (Cl B) and elimination half life (t 1/2β) of cefepime were 0.27±0.05 h, 1.05±0.09 L kg -1, 2.38±0.2 L h -1 kg -1 and 5.13±0.27 h, respectively. No significant changes were reported in pharmacokinetic parameters following co-administration of cefepime with ketoprofen. While under febrile state, all pharmacokinetic parameter of cefepime remained non-significantly altered except elimination half life (6.64±0.33 h) and peak serum concentration (39.23±1.11 μg mL -1). Cefepime pharmacokinetic data generated from the present study suggest that the drug can be administered intramuscularly (20 mg kg -1) with ketoprofen and in febrile condition at 12 h interval to combat susceptible bacterial infections in goats. © 2012 Academic Journals Inc.