Synthesis and cytotoxic activity of methyl glycyrrhetinate esterified with amino acids

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Abstract

Methyl glycyrrhetinate was esterified at position C3 of ring A using different amino acids. A short, unbranched chain of four carbon atoms with two amino groups in positions 2 and 4 was shown to be the most active compound of this series (IC50 = 0:8 M on liposarcoma Lipo cells). These compounds trigger apoptosis as shown by an acridine orange/ethidium bromide assay, trypan blue tests and DNAladdering experiments. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen.

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Csuk, R., Schwarz, S., Siewert, B., Kluge, R., & Ströhl, D. (2012). Synthesis and cytotoxic activity of methyl glycyrrhetinate esterified with amino acids. Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences, 67(7), 731–746. https://doi.org/10.5560/ZNB.2012-0107

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