In this work, supercritical carbon dioxide was used as reaction media in the lipase-mediated epoxidation of alkenes for the first time. Under the optimal conditions (alkene (1 mmol), novozym 435 (15 mg), H2 O2 (50% aqueous solution, 1.4 mmol), n-caprylic acid (0.05 mmol), 40°C, scCO2 (10 MPa, 25 mL)), high yields (83–98%) of epoxidation of alkenes could be obtained in a short reaction time. Furthermore, novozym 435 exhibited a satisfactory reusability in the epoxidations. Thus, this work not only presents a green and mild method of lipase-mediated epoxidation with higher yield and reaction rate than other lipase-mediated routes ever reported but also expands the application of supercritical carbon dioxide in enzyme catalytic promiscuity.
CITATION STYLE
Zhang, J., Qian, W., Wang, C., Cao, Z., Chen, S., Zhang, L., … Wang, L. (2018). Lipase-mediated epoxidation of alkenes in supercritical carbon dioxide. Green Chemistry Letters and Reviews, 11(4), 508–512. https://doi.org/10.1080/17518253.2018.1543456
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