The closely related mitogen-activated protein kinases ERK1 and ERK2 have now been shown to have opposing roles in Ras-mediated cell proliferation. I propose that dimerization of these highly related protein kinases could underlie these surprising observations and that this could be a common paradigm for widespread regulation of protein phosphorylation by kinase-substrate interactions. © 2006 BioMed Central Ltd.
CITATION STYLE
Pelech, S. (2006). Dimerization in protein kinase signaling. Journal of Biology. https://doi.org/10.1186/jbiol45
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