Evaluating systems pharmacology models is different from evaluating standard pharmacokinetic-pharmacodynamic models

Abstract

Based on the author's recent experience, there appears to be some confusion regarding the steps required to qualify a systems pharmacology model as adequate for the intended purpose. This manuscript outlines the model evaluation approach used in the author's recent publication1 on the systems pharmacology of a 5-lipoxygenase inhibitor and is an attempt to generate discussion on this topic within the pharmacometrics and systems pharmacology community. © 2014 ASCPT All rights reserved.