Failure of intrahypothalamic implants of antiestrogen, MER-25, to inhibit androgen-sterilization in female rats

Abstract

Two-day-old female rats were given bilateral implants of small pellets each containing 5 μg MER-25 in bone wax in the medial preoptic to ventromedial areas of the hypothalamus. At the same time, the rats received a single subcutaneous injection of 50 μg testosterone propionate. Ovaries of the rats were examined by laparotomy for the presence of corpora lutea at 50 days of age. At 100 days, ovaries were removed and studied histologically. Sterilizing action of testosterone propionate was not inhibited by intrahypothalamic implants of MER-25, at least the present experimental conditions. © 1974, The Japan Endocrine Society. All rights reserved.