Effect of theophylline on differentiation of Trypanosoma brucei

17Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Differentiation of Trypanosoma brucei in the mammal limits the degree of parasitemia and prepares the trypanosome for passage back into the tsetse fly. In an attempt to define the signals that control differentiation, we found that theophylline, in contrast to indomethacin, blocked differentiation, prolonged parasitemia, elevated prostaglandin and cyclic AMP concentrations of rat plasma, and depressed intratrypanosomal cyclic AMP. Relatively nontoxic drugs that alter differentiation are powerful tools for elucidating the events that control this important process.

Cite

CITATION STYLE

APA

Reed, S. L., Fierer, A. S., Goddard, D. R., Colmerauer, M. E. M., & Davis, C. E. (1985). Effect of theophylline on differentiation of Trypanosoma brucei. Infection and Immunity, 49(3), 844–847. https://doi.org/10.1128/iai.49.3.844-847.1985

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free